##fileformat=VCFv4.1
##FILTER=<ID=PASS,Description="All filters passed">
##reference=GRCh38-hg38
##contig=<ID=chr7>
##contig=<ID=chr14>
##contig=<ID=chr17>
##pipeline_annotation_tool=GPF variant annotation.
##INFO=<ID=worst_effect,Number=A,Type=String,Description="Worst effect across all transcripts.">
##INFO=<ID=genes,Number=A,Type=String,Description="Comma separated list of all affected genes.">
##INFO=<ID=phyloP7way,Number=A,Type=String,Description="The score is a number that reflects the conservation at a position.">
##INFO=<ID=CLNSIG,Number=A,Type=String,Description="Aggregate germline classification for this single variant; multiple values are separated by a vertical bar">
##INFO=<ID=CLNDN,Number=A,Type=String,Description="ClinVar's preferred disease name for the concept specified by disease identifiers in CLNDISDB">
#CHROM	POS	ID	REF	ALT	QUAL	FILTER	INFO
chr14	21415880	.	G	A	.	.	worst_effect=nonsense;genes=CHD8;phyloP7way=0.917;CLNSIG=Pathogenic/Likely_pathogenic;CLNDN=not_provided|Intellectual_developmental_disorder_with_autism_and_macrocephaly
chr17	7674904	.	TCT	T	.	.	worst_effect=frame-shift;genes=TP53;phyloP7way=-0.12;CLNSIG=Pathogenic;CLNDN=Hereditary_cancer-predisposing_syndrome|TP53-related_disorder|not_provided|Li-Fraumeni_syndrome_1|Ovarian_neoplasm|Li-Fraumeni_syndrome
chr7	117587806	.	G	A	.	.	worst_effect=missense;genes=CFTR;phyloP7way=0.917;CLNSIG=Pathogenic;CLNDN=CFTR-related_disorder|Cystic_fibrosis|Congenital_bilateral_aplasia_of_vas_deferens_from_CFTR_mutation|not_provided|Hereditary_pancreatitis|Bronchiectasis_with_or_without_elevated_sweat_chloride_1|ivacaftor_response_-_Efficacy