GPF (Genotypes and Phenotypes in Families) is an open-source platform that manages genotypes and phenotypes derived from collections of families. The GPF interface allows interactive exploration of genetic variants, enrichment analysis for de novo mutations, and phenotype/genotype association tools. In addition, GPF allows researchers to share their data securely with the broader scientific community. See the The Genotype and Phenotypes in Families (GPF) platform manages the large and complex data at SFARI for detailed description.
GPF is an open-source project available at GitHub developed by Iossifov's group at CSHL and Seqpipe Ltd, Sofia, Bulgaria.
The documentation is available at https://iossifovlab.com/gpfuserdocs/index.html
GPF is deployed at the Simons Foundation (https://gpf.sfari.org), providing protected access to comprehensive genotypic and phenotypic data for the SSC, SPARK, and related datasets.
Tutorial videos: